Relación entre microbiota intestinal y sarcopenia en pacientes con enfermedad de parkinson. Revisión

Abstract

Background: Parkinson's disease (PD) is a neurodegenerative disease that presents various motor and nonmotor manifestations. Sarcopenia is present in one of five patients with PD, associated with the severity of the disease contributing to increase in morbidity and mortality of those who suffer from it. Researchers have found that patients with PD present an alteration of the bacteria residing in the digestive system establishing an axis gut-brain that would explain much of the complications in PD but there also exists the axis intestinemuscle that would explain some causes of the severity of the sarcopenia in patients with PD. The objective was to analyze the existence between gut microbiota and sarcopenia in persons that have Parkinson's disease Methods: The following data bases were used: NCBI, EBSCO, ProQuest, applying the key words and MeSH: (“gut microbiota” OR microbiota OR microbiome OR flora) AND sarcopenia AND Parkinson. Results: The first finding did not yield results therefore deciding to delete the filters even so the result was not satisfactory. The second finding was carried out by eliminating Parkinson's disease and after applying the filters established 1 paper was obtained which meets with the objective of the review. Due to the limited results, it was decided to carry out the review as a narrative. Conclusions: The evidence found makes think that the relation existing between the MI and Sarcopenia in patients with PD is the activation of the inflammatory state, which derives from the interaction of intestinal bacteria with the immune system.