Modificaciones estructurales y ultraestructurales en la mucosa gastrointestinal por acción de radicales libres. Posible efecto protector del etanol

  1. Falcón Romero, M. 1
  2. Gómez Zapata, M. 1
  3. Vicente Ortega, V. 1
  4. Martínez Díaz, F.J. 1
  5. Ordóñez Escudero, D. 2
  6. Luna Maldonado, A. 1
  1. 1 Universidad de Murcia
    info

    Universidad de Murcia

    Murcia, España

    ROR https://ror.org/03p3aeb86

  2. 2 Universidad de León
    info

    Universidad de León

    León, España

    ROR https://ror.org/02tzt0b78

Revue:
Revista de toxicología

ISSN: 0212-7113

Année de publication: 2001

Volumen: 18

Número: 2

Pages: 72-74

Type: Article

DIALNET GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: Revista de toxicología

Résumé

The aim of this work was to study the histological modifications of the gastrointestinal mucosa when exposed to free radicals and to ascertain whether athanol can reduce the damage caused by these free radicals. For this, we studied structural and ultrastructural modifications of the gastrointestinal mucosa of rats treated with Fenton reagent (a free radical producer) with or without added ethanol. At the structural level, the results pointed to more inflamatory lesions in the rats treated with Fenton reagent alone. At the ultrastructural level, on the other hand, no differences were observed between the kind of cellular lesions found in rats treated with Fenton reagent and those found in rats treated with both Fenton reagent and ethanol, sice all the lesions were unspecific and appeared with the same frecuency. Due to the lack of specificity in the histological alterations produced by free radicals, such alterations can only reflect the intensity but not the etiology of the damage produced.

Références bibliographiques

  • Halliwell, B., Gutteridge, J.M.C., Oxygen toxicity, oxygen radicals, transition metals and disease (1984) Biochem J, 219, pp. 1-14
  • Halliwell, B., Free radicals and metals ions health and disease (1987) Proc. Nutr. Sos, 46, pp. 13-26
  • Slivka, A., Kang, J., Cohen, G., Hydroxyl radicals and the toxicity of oral iron (1986) Biochem Pharmacol, 35, pp. 553-556
  • Samuni, A., Aranovitch, J., Gordinger, D., Chevion, M., Czapski, G., On the cytotoxicity of vitamin C and metal ions (1983) Eur. J. Biochem, 137, pp. 119-124
  • Cederbaum, A.I., Oxygen radicals generation by microsomes: Role of iron and implications for alcohol metabolism and toxicity (1989) J. Free. Radic. Biol. Med, 7, pp. 559-567
  • Nordmaun, R., Ribiere, C., Ronach, H., Involvement of iron and iron-catalyzed free radical. Production in ethanol metabolism and toxicity (1987) Enzyme, 37, pp. 57-69
  • Carrión Alcaraz, C., Roldan Ortega, R., Gomez Zapata, M., Sanchez Garcia, J.A., Luna Maldonado, A., Cinética de formación de radicales libres en jugo gástrico humano (1991) Rev. Toxicol, 8, pp. 379-387
  • Mizui, T., Sato, H., Hirose, F., Doteuchi, M., Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats (1987) Life. Sci, 41, pp. 755-763
  • Szelenyi, I., Brune, K., Possible role of oxygen free radicals in ethanol induced gastric mucosal damage in rats (1988) Dig. Dis. Sci, 33, pp. 865-871
  • Puurunen, J., Laitinen, L.A., Gastric mucosal oxidation of ethanol is not involved in ethanol-induced mucosal damage (1982) Toxicol. Lett, 14, pp. 195-200
La source de données: Dialnet