Analysis of volatile organic compounds in asthmatic mothers as tool for finding asthma biomarkers in early childhood

  1. R.A. Sola
  2. J.M. Pastor
  3. E. Cantero-Cano
  4. T. De Diego 3
  5. L. García-Marcos 2
  6. M.T. Prieto-Sánchez
  7. C. Martínez-Gracia 1
  8. A. Gázquez-García
  9. A. Torres-Cantero
  10. G. Yagüe
  11. J. Cabezas
  12. A. Esteban-Gil
  13. R. Castillo
  14. C. Ballesteros
  15. M. Cánovas 3
  1. 1 Universidad de Murcia, Nutrición y Bromatología
  2. 2 Universidad de Murcia, Pediatría
  3. 3 Universidad de Murcia, Departamento de Bioquímica y Biología Molecular B e Inmunología
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Liburua:
IV Jornadas Doctorales Escuela Internacional de Doctorado de la Universidad de Murcia (Eidum)

Argitaletxea: Servicio de Publicaciones ; Universidad de Murcia

ISBN: 978-84-09-09200-0

Argitalpen urtea: 2019

Orrialdeak: 225-231

Biltzarra: IV Jornadas Doctorales Escuela Internacional de Doctorado de la Universidad de Murcia (EIDUM) (4. 2018. Murcia)

Mota: Biltzar ekarpena

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Laburpena

As it is widely reported, asthma has become the most prevalent paediatric chronic res-piratory disease (Moschino, Zanconato, Bozzetto, Baraldi, & Carraro, 2015). Inflammation and reversible obstruction of airways, and bronchial hyperresponsiveness are the most common symptoms of asthma (Moschino et al., 2015). Currently, it does not exist a suitable and non-invasive method for early diagnosis of asthma in babies (Smolinska et al., 2014). Thus, profile analysis of volatile organic compounds (VOCs) in exhaled breath from small children can be used as potential approach (Smolinska et al., 2014). Human exhaled breath contains a great variety of VOCs (Amann et al., 2014). Some studies have shown important VOCs profiles differences in people (Amann et al., 2014). These variations are influenced by different factors (metabolism, respiratory diseases, environmental factors, etc.) (Amann et al., 2014). Although VOCs can have different origins, there are many endogenous com-pounds which are produced by different inflammatory and metabolic pathways (van de Kant, van der Sande, Jöbsis, van Schayck, & Dompeling, 2012). In this work, exhaled breath samples of three-months-old children (n = 208) were col-lected for the first time along with mothers’ exhaled breath and room air samples (used as blank). Every sample set (child, mother and room air sample) was analysed by a coupled system of thermal desorption and gas chromatography-mass spectrometry (TD-GC-MS). In addition, data obtained for each sample set were treated and processed for a preliminary statistical analysis by performing principal component analysis (PCA) with RStudio software. Some studies reported associations between parental history of asthma and asthma risk in children, specially early onset persistent asthma (London, James Gauderman, Avol, Rap-paport, & Peters, 2001). The aim of this research is to find out specific features in children with asthmatic mother. In a first stage, several endogenous VOCs from mothers’ exhaled breath (acetone, acetaldehyde, isoprene, hexanal, heptanal, octanal and nonanal) were selected. Such levels were checked to find out significant differences between healthy and asthmatic mothers. In a second stage, a correspondence analysis between family history of asthma and respiratory diseases in babies was performed. This information will help gain-ing insights which allow a more accurate diagnosis of asthma in childhood.

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