Learning from yeastsintracellular sensing of stress conditions
- Mariano José Gacto Fernández 1
- Teresa Soto Pino 1
- María Jerónima Vicente Soler 1
- Tomás González Villa 2
- José Cansado Vizoso 1
- 1 Department of Genetics and Microbiology, University of Murcia, Spain
- 2 Department of Microbiology and Parasitology, University of Santiago de Compostela, Spain
ISSN: 1618-1905
Ano de publicación: 2003
Volume: 6
Número: 3
Páxinas: 211-219
Tipo: Artigo
Outras publicacións en: International microbiology: official journal of the Spanish Society for Microbiology
Obxectivos de Desenvolvemento Sustentable
Resumo
One intriguing challenge in modern biology is to understand how cells respond to, and distinguish between different stressing stimuli. Evidence accumulated in recent years indicates that a network of signaling pathways extends from the plasma membrane to the very core of the cell nucleus to transduce environmental changes into a graded transcriptional response. Although many steps still remain unclear, studies on the stress-activated protein kinase (SAPK) pathways and related mechanisms provide insight into the biochemistry that regulates signal transmission and leads to outcomes such as cell adaptation and differentiation. This review focuses on selected topics of current interest related to the sensing of stress signals in cells of the fission yeast Schizosaccharomyces pombe. Because signaling pathways appear to be evolutionarily well conserved, yeasts may be useful models to learn how higher eukaryotes sense and respond to stresses at the cellular level.