Publicaciones en colaboración con investigadores/as de University of Manchester (23)

2016

  1. Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

    Cell Death and Differentiation, Vol. 23, Núm. 7, pp. 1219-1231

2015

  1. AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Núm. 13, pp. 4050-4055

  2. Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

    Journal of Immunology, Vol. 194, Núm. 3, pp. 1261-1273

2014

  1. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

    Nature Immunology, Vol. 15, Núm. 8, pp. 738-748

2013

  1. Response to Boyle et al.

    Immunity

2012

  1. A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity

    Journal of Immunology, Vol. 189, Núm. 5, pp. 2131-2137

  2. Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

    Immunity, Vol. 37, Núm. 3, pp. 487-500

  3. Current status of inflammasome blockers as anti-inflammatory drugs

    Expert Opinion on Investigational Drugs, Vol. 21, Núm. 7, pp. 995-1007

2011

  1. Novel macrophage polarization model: From gene expression to identification of new anti-inflammatory molecules

    Cellular and Molecular Life Sciences, Vol. 68, Núm. 18, pp. 3095-3107

  2. P2X 7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

    Oncogene, Vol. 30, Núm. 18, pp. 2108-2122

  3. P2X7 receptor antagonism in the treatment of cancers

    Expert Opinion on Investigational Drugs, Vol. 20, Núm. 7, pp. 875-880

2010

  1. C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation

    Journal of Biological Chemistry, Vol. 285, Núm. 23, pp. 17514-17524

  2. P2X7 receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases

    Journal of Immunology, Vol. 185, Núm. 4, pp. 2611-2619

2009

  1. Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1Β release through pyrophosphates

    EMBO Journal, Vol. 28, Núm. 14, pp. 2114-2127

  2. Pannexin-1-dependent caspase-1 activation and secretion of IL-1β is regulated by zinc

    European Journal of Immunology, Vol. 39, Núm. 2, pp. 352-358

  3. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells

    Journal of Pharmacology and Experimental Therapeutics, Vol. 328, Núm. 2, pp. 409-418

  4. The P2X7 receptor - Pannexin connection to dye uptake and IL-1β release

    Purinergic Signalling, Vol. 5, Núm. 2, pp. 129-137

2008

  1. Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding

    Journal of Neuroscience, Vol. 28, Núm. 25, pp. 6393-6401

  2. P2X7 receptor differentially couples to distinct release pathways for IL-1β in mouse macrophage

    Journal of Immunology, Vol. 180, Núm. 11, pp. 7147-7157

  3. Targeting Interleukin-1 Signaling in Chronic Inflammation: Focus on P2X<sub>7</sub> Receptor and Pannexin-1

    DRUG NEWS & PERSPECTIVES, Vol. 21, Núm. 8, pp. 424-433