Role of body mass index in unbalanced (dysanaptic) lung growth of healthy infants

  1. Sanchez‐Solis, Manuel 13
  2. Forno, Erick 4
  3. Morales, Eva 12
  4. Garcia‐Marcos, Luis 3
  5. The NELA Study Group
  1. 1 Pediatric Research Department Biomedical Research Institute of Murcia (IMIB) Murcia Spain
  2. 2 Department of Public Health Sciences University of Murcia Murcia Spain
  3. 3 Pediatric Pulmonology Unit Pediatric Service, Virgen de la Arrixaca University Children's Hospital of Murcia Murcia Spain
  4. 4 Pulmonary, Allergy, and Sleep Medicine, Riley Hospital for Children and Department of Pediatrics Indiana University School of Medicine Indiana USA
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Zeitschrift:
Pediatric Pulmonology

ISSN: 8755-6863,  1099-0496

Datum der Publikation: 2024

Art: Artikel

DOI: 10.1002/PPUL.27161 GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: Pediatric Pulmonology

Zusammenfassung

RationaleImbalance between forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) (dysanapsis) has been reported in children who are obese. This dysanaptic growth might begin at an early age, although there are no data on children younger than 6 years.ObjetivesTo assess whether body mass index (BMI) and early weight gain, in healthy infants born at term, plays a significant role in the imbalance between FEV1 and FVC, even in the absence of obesity.MethodsLung function was measured by means of raised volume rapid thoracic compression in 69 healthy infants born at term from the Nutrition in Early Life and Asthma cohort. Dysanapsis was defined as zFVC >0.674, zFEV0.5 ≥−1.645, and FEV0.5/FVC ≤−1.645. Weight gain (g/day) and growth rate (cm/year) were calculated as the difference between weight and length on the test date and those at birth. To assess the relationship between zBMI and dysanapsis, a receiver operating characteristic curve was performed. Multivariable analysis was carried out by means of linear regressions (one for each lung function index) and by logistic regression for dysanapsis (yes/no).ResultsHigher zBMI was associated with risk of dysanapsis (odds ratio: 3.53, [95% confidence interval: 1.30; 9.66]; p = .014): Each additional zBMI unit was associated with ~10 mL higher FVC and with ~3.5% lower FEV0.5/FVC. Weight gain was associated with lower FEV0.5/FVC ratio.ConclusionDysanaptic development of lung function begins very early in infancy and is related with weight gain and body mass index, even in the absence of obesity.

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