Congenital bilateral clinical anophthalmia and brachygnathia superior in a fighting bull calf

  1. Seva, Juan 1
  2. Sanes, José Manuel 1
  3. Bueno, Juan Manuel 2
  4. De Jódar, Carlos 1
  5. Soler, Marta 3
  6. Bayón, Alejandro 3
  7. Párraga‐Ros, Ester 1
  1. 1 Department of Anatomy and Comparative Pathology, Veterinary Teaching Hospital University of Murcia Murcia Spain
  2. 2 Optics Laboratory, Center for Research in Optics and Nanophysics University of Murcia Murcia Spain
  3. 3 Department of Animal Medicine and Surgery, Veterinary Teaching Hospital University of Murcia Murcia Spain
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Revista:
Clinical Case Reports

ISSN: 2050-0904,  2050-0904

Año de publicación: 2023

Volumen: 11

Número: 5

Tipo: Artículo

DOI: 10.1002/CCR3.7159 WoS: WOS:000989296600001 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Clinical Case Reports

Resumen

This study describes a case of a 20-day-old male fighting bull with bilateral clinical anophthalmia and brachygnathia superior whose dam was 12.5years old and was mistakenly dewormed with ivermectin intramuscularly in the first third of gestation in a livestock farm. A macroscopic examination of the carcass was performed, with a special focus on the ocular components. Eyeball remains were found in both orbits and a histopathological examination was performed on them. Antibodies by serological study against bovine herpes virus-1, respiratory syncytial virus and bovine viral diarrhea virus for both the cow and the calf were not detected. The calf had small orbits and inside them a white and brown mass of soft consistency. Microscopically, abundant muscular and adipose tissue was observed, alongside nervous structures and vestiges of ocular structures with stratified epithelium and abundant connective tissue with glands. No evidence that this congenital bilateral anophthalmia had infectious or hereditary origin was found. By contrast, the malformation could be related to the treatment with ivermectin during the first month of gestation.

Referencias bibliográficas

  • Bähr C, Kuiper H, Distl O. Bilateral anophthalmia associated with further anomalies of the head in German Holstein calves.Dtsch Tierarztl Wochenschr. 2003;110:454-456.
  • Moritomo Y, Koga O, Miyamoto H. Unilateral anophthalmia in a Holstein calf. J Vet Med Sci. 1994;56:153-155.
  • Moritomo Y, Koga O, Miyamoto H, Tsuda T. Congenital anophthalmia with caudal vertebral anomalies in Japanese Brown cattle. J Vet Med Sci. 1995;57:693-696.
  • Verma AS, FitzPatrick DR. Anophthalmia and microphthalmia. Orphanet J Rare Dis. 2007;2:47.
  • Pearce JW, Moore CP. Food animal ophthalmology. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Wiley-Blackwell; 2013:1610-1674.
  • Leipold HW, Huston K. Congenital syndrome of anophthalmia–microphthalmia with associated defects in cattle. Pathol Vet. 1968;5:407-418.
  • Konno S, Moriwaki M, Nakagawa M. Akabane disease in cattle: congenital abnormalities caused by viral infection. Spontaneous disease. Vet Pathol. 1982;19:246-266.
  • Scott FW, Kahrs RF, De Lahunte A. Virus induced congenital anomalies of the bovine fetus. I. Cerebellar degeneration (hypoplasia), ocular lesions and fetal mummification following experimental infection with bovine viral diarrhea-mucosal disease virus. Cornell Vet. 1973;63:536-560.
  • Meruane M, Smok C, Rojas M. Face and neck development in vertebrates. Int J Morphol. 2012;30:1373-1388.
  • Makhoul IR, Soudack M, Kochavi O, Guilburd JN, Maimon S, Gershoni-Baruch R. Anophthalmia-plus syndrome: a clinical report and review of the literature. Am J Med Genet A. 2007;143:64-68.
  • Miura Y, Goto Y, Kono Y, et al. Bovine abnormal birth due to viral infection-relationship between bovine abnormal birth and arthropod-borne virus infection. Jpn J Vet Med Assoc. 1987;40:473-478.
  • Szabo KT. Sensory system. In: Szabo KT, ed. Congenital Malformations in Laboratory and Farm Animals. Academic Press; 1989:245-268.
  • Bistner SI, Rubin L, Aguirre G. Development of the bovine eye. Am J Vet Res. 1973;34:7-12.
  • Elliott GB, Tredwell SJ, Elliott KA. The notochord as an abnormal organizer in production of congenital intestinal defect. Am J Roentgenol Radium Ther Nucl Med. 1970;110:628-634.
  • El-Ashmawy IM, El-Nahas AF, Bayad AE. Teratogenic and cytogenetic effects of ivermectin and its interaction with Pglycoprotein inhibitor. Res Vet Sci. 2011;90:116-123.
  • Nicolas P, Maia MF, Bassat Q, et al. Safety of oral ivermectin during pregnancy: a systematic review and meta-analysis. Lancet Glob Health. 2020;8:92-100.
  • Lifschitz A, Virkel G, Pis A, et al. Ivermectin disposition kinetics after subcutaneous and intramuscular administration of an oil-based formulation to cattle. Vet Parasitol. 1999;86:203-215
  • FDA/CDER SBIA Chronicles. Drugs in pregnancy and lactation: improved benefit-risk information. Accessed June 1, 2020. ttps://www.fda.gov/files/drugs/published/%22Drugs-inPregnancy-and-Lactation--Improved-Benefit-Risk-Informatio n%22-January-22--2015-Issue.pdf