Choroidal Thickness Analysis in Keratoconus Patients

  1. A. López-Jiménez
  2. A. Caravaca-Alegría
  3. A. M. Gómez-Ramírez
  4. M. D. Romero-Caballero
  5. C. Gómez-Sánchez
  6. J. Lacorzana
Revista:
Actualidad médica

ISSN: 0365-7965

Año de publicación: 2021

Tomo: 106

Número: 814

Páginas: 252-259

Tipo: Artículo

DOI: 10.15568/AM.2021.814.OR02 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Actualidad médica

Resumen

Objetivo. Determinar y comparar el grosor de la coroides (CT) en pacientes con queratocono (KC) usando OCT con Enhanced Depth Imaging (EDI). Métodos. Estudio comparativo transversal que incluye 26 pacientes con KC y 26 controles sanos evaluados con Pentacam y EDI-OCT. El KC fue medido manualmente con la función Caliper en trece puntos a intervalos regulares de 500 µm. Resultados. El promedio de CT en T6 fue de 253,96 ± 88,95 μm en el grupo KC, y de 309,39 ± 94,11 μm en el grupo de control (p <0,041). No se observaron diferencias significativas en la media de CT en el resto de los puntos, incluyendo el CT subfoveal (M), 351.48 ± 106.3 vs 365.35 ± 114.6 μm, (p = 0.66). No se observó ninguna correlación entre la media de CT (M) subfoveal, la media de CT en el grupo KC, y los valores de K1 (p = 0,977 y p = 0,498 respectivamente), K2 (p = 0,450 y p = 0,656), la asfericidad corneal (Q) (p = 0,986 y p = 0. 902), paquimetría mínima (Pachy) (p = 0,408 y p = 0,688), índice de queratocono (KI) (p = 0,601 y p = 0,217), índice de asimetría vertical (VIA) (p = 0,296 y p = 0,523), estadificación del KC (TKC) (p = 0,549 y p = 0,08) y morfología del ápice corneal. Conclusión. Se observó un CT significativamente menor en el grupo KC en T6 (3000 μm temporal a la fóvea). No se encontraron diferencias significativas entre los valores del CT en los pacientes con KC y en los sujetos sanos en los 12 puntos de medida restantes. No se encontró ninguna asociación entre los índices refractivos y queratométricos obtenidos por la topografía corneal y el CT subfoveal.

Referencias bibliográficas

  • Akkaya Macular and peripapillary choroidal thickness in patients with keratoconus. Ophthalmic Surg Lasers Imaging Retin. 2018 Sep 1;49(9):664–73. DOI: 10.3928/23258160-20180831-03
  • Assiri AA, Yousuf BI, Quantock AJ, Murphy PJ, Assiri Incidence and severity of keratoconus in Asir province, Saudi Arabia. Br J Ophthalmol. 2005 Nov;89(11):1403–6. DOI: 10.1136/bjo.2005.074955
  • Balasubramanian SA, Pye DC, Willcox Are proteinases the reason for keratoconus. Curr Eye Res; 2010 Mar;35(3)185-191. DOI: 10.3109/02713680903477824
  • Beckh U, Schonherr U, Naumnnn GOH. Autosomal inherited keratoconus as an ocular symptom of osteogenesis imperfecta tarda Lobstein. Klin Monbl Augenheilkd. 1995 Apr 8;206(4):268–72. DOI: 1055/s-2008-1035438
  • Boote C, Kamma-Lorger CS, Hayes S, Harris J, Burghammer M, Hiller J, et al. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophys J. 2011 Jul 6;101(1):33–42. DOI: 10.1016/j.bpj.2011.05.029
  • Collier SA. Is the corneal degradation in keratoconus caused by matrix-metalloproteinases? 29, Clinical and Experimental Ophthalmology. Blackwell Publishing; 2001. p. 340–4. DOI: 10.1046/j.1442-9071.2001.d01-17.x
  • Davidson AE, Hayes S, Hardcastle AJ, Tuft The pathogenesis of keratoconus. Eye. 2014;28(2):189–95. DOI: 10.1038/eye.2013.278
  • Ferreira CS, Beato J, Falcão MS, Brandão E, Falcão-Reis F, Carneiro ÂM. Choroidal thickness in multisystemic autoimmune diseases without ophthalmologic manifestations. 2017 Mar;37(3): 529–535. DOI: 10.1097/iae.0000000000001193
  • Fleischman D, Say EAT, Wright JD, Landers Multimodality diagnostic imaging in a case of sympathetic ophthalmia. Ocul Immunol Inflamm. 2012 Aug;20(4)300–302. DOI: 10.3109/09273948.2012.682637
  • Fong AHC, Li KKW, Wong Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina. 2011 Mar;31(3):502–509. DOI: 10.1097/iae.0b013e3182083beb
  • Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera Keratoconus: An inflammatory disorder? Eye (Basingstoke). Nature Publishing Group; 2015 Jul;29(7):843–859. DOI: 10.1038/eye.2015.63
  • Gokhale Epidemiology of keratoconus. In: Indian J Ophthalmol. Medknow Publications and Media Pvt. Ltd.; 2013. Aug; 61(8)382–383. DOI: 10.4103/0301-4738.116054
  • Gutierrez-Bonet R, Ruiz-Medrano J, Peña-Garcia P, Catanese M, Sadeghi Y, Hashemi K, et al. Macular choroidal thickening in keratoconus patients: Swept-source optical coherence tomography Transl Vis Sci Technol. 2018 May 1;7(3):15–15. DOI: 10.1167/tvst.7.3.15
  • Harrison RJ, Klouda PT, Easty DL, Manku M, Charles J, Stewart Association between keratoconus and atopy. Br J Ophthalmol. 1989 Oct 1;73(10):816–22. DOI: 10.1136/bjo.73.10.816
  • Hashemi H, Khabazkhoob M, Yazdani N, Ostadimoghaddam H, Norouzirad R, Amanzadeh K, et al. The prevalence of keratoconus in a young population in Mashhad, Iran. Ophthalmic Physiol 2014;34(5):519–27. DOI: 10.1111/opo.12147
  • Hirukawa K, Keino H, Watanabe T, Okada AA. Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute posterior scleritis. Vol. 251, Graefes Arch Clin Exp Ophthalmol. 2013 Sep; 251(9): 2273–2275. DOI: 10.1007/s00417-013-2265-z
  • Ishikawa S, Taguchi M, Muraoka T, Sakurai Y, Kanda T, Takeuchi Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behçet’s disease. Br J Ophthalmol. 2014 Nov 1;98(11):1508–1513. DOI: 10.1136/bjophthalmol-2014-305333
  • Jonas JB, Nangia V, Matin A, Kulkarni M, Bhojwani Prevalence and Associations of Keratoconus in Rural Maharashtra in Central India: The Central India Eye and Medical Study. Am J Ophthalmol. 2009 Nov;148(5):760– 5. DOI: 10.1016/j.ajo.2009.06.024
  • Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, et Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS One. 2011 Jan 27;6(1):e16437. DOI: 10.1371/journal.pone.0016437
  • Lema I, Brea D, Rodríguez-González R, Díez-Feijoo E, Sobrino Proteomic analysis of the tear film in patients with keratoconus. Mol Vis. 2010;16:2055–61.
  • Lema I, Durán JA, Ruiz C, Díez-Feijoo E, Acera A, Merayo Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects. Cornea. 2008 Aug;27(7):758–63. DOI: 10.1097/ico.0b013e31816a3591
  • Li KZ, Tan Evaluation of choroidal thickness in psoriasis using spectral-domain optical coherence tomography. Int Ophthalmol. 2018 Apr; 38(2)417–8. DOI: 10.1007/s10792-017-0527-1
  • Li X, Rabinowitz YS, Tang YG, Picornell Y, Taylor KD, Hu M, et Two-stage genome-wide linkage scan in kera- toconus sib pair families. Investig Ophthalmol Vis Sci. 2006 Sep 1;47(9):3791–5. DOI: 10.1167/iovs.06-0214
  • Lichter H, Loya N, Sagie A, Cohen N, Muzmacher L, Yassur Y, et al. Keratoconus and mitral valve Am J Ophthalmol. 2000;129(5):667–8. DOI: 10.1016/s0002-9394(00)00371-8
  • Margolis R, Spaide A Pilot Study of Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes. Am J Ophthalmol. 2009 May;147(5):811–5. DOI: 10.1016/j.ajo.2008.12.008
  • Marshall GE, Konstas AG, Lee WR. Immunogold fine structural localization of extracellular matrix components in aged human cornea Collagen types V and VI. Graefe’s Arch Clin Exp Ophthalmol. 1991;229(2):164–71. DOI: 10.1007/bf00170550
  • McDermott ML, Holladay J, Liu D, Puklin JE, Shin DH, Cowden JW. Corneal topography in Ehlers-Danlos syndrome. J Cataract Refract Surg. 1998;24(9):1212–5. DOI: 1016/s0886-3350(98)80013-8
  • McMonnies Abnormal rubbing and keratectasia. Eye Contact Lens. 2007. 33(6)265–271. DOI: 10.1097/icl.0b013e31814fb64b
  • McMonnies CW, Korb DR, Blackie The role of heat in rubbing and massage-related corneal deformation. Vol. 35, Contact Lens and Anterior Eye. 2012. p. 148–54. Available from: DOI: 10.1016/j.clae.2012.01.001
  • McMonnies Inflammation and keratoconus. Optom Vis Sci. 2015 feb;92(2)35-41. DOI: 10.1097/opx.0000000000000455
  • Pinheiro-Costa J, Pinto JV, Perestrelo S, Beato JN, Torrão L, Brandão E, et Increased Choroidal Thickness in Keratoconus Patients: Perspectives in the Disease Pathophysiology. J Ophthalmol. 2019 Dec 3;2019:2453931. DOI:10.1155/2019/2453931
  • Rabinowitz Keratoconus. Sur Ophthalmol 1998. 42(4): 297319. DOI: 10.1016/S0039-6257(97)00119-7
  • Sezer T, Altınışık M, Koytak İA, Özdemir MH. The choroid and optical coherence Turk Oftalmoloiji Dergisi. Turk J Ophthalmol; 2016 Jan; 46(1)30–37. DOI: 10.4274/tjo.10693
  • Toprak I, Kucukatay V, Yildirim C, Kilic-Toprak E, Kilic-Er-kek O. Increased systemic oxidative stress in patients with keratoconus. 2014;28(3):285–9. DOI: 10.1038/eye.2013.262
  • Wang Y, Rabinowitz YS, Rotter JI, Yang Genetic epidemiological study of keratoconus: Evi- dence for major gene determination. Am J Med Genet. 2000 Aug 28;93(5):403–9. DOI: 10. 1002/1096-8628( 20000828)93:5<403::AID-AJM-G11>3.0.CO;2-A
  • Wojcik KA, Kaminska A, Blasiak J, Szaflik J, Szaflik Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy. Vol. 14, Int J Mol Sci. 2013; 14(9):19294–19308. DOI: 10.3390/ijms140919294
  • Yilmaz I, Saracoglu Yilmaz B, Guleryuz NB, Perente I, Ozkaya A, Taskapili Assessment of the macula and choroid in pediatric keratoconus patients. Saudi J Ophthalmol. 2018 Apr 1;32(2):126–9. DOI: 10.1016/j.sjopt.2017.10.010
  • Zhou L, Yue BYJT, Twining SS, Sugar J, Feder RS. Expression of wound healing and stress-related proteins in keratoconus corneas. Curr Eye 1996;15(11):1124–1131. DOI: 10.3109/02713689608995144