Beneficios de los compuestos bioactivos del mangostán en la enfermedad de AlzheimerRevisión narrativa

  1. Inmaculada Navarro González
  2. Pedro Andreo Martínez
  3. Nuria García Martínez
Revista:
Revista de Discapacidad, Clínica y Neurociencias: (RDCN)

ISSN: 2341-2526

Ano de publicación: 2021

Volume: 8

Número: 1

Páxinas: 28-38

Tipo: Artigo

DOI: 10.14198/DCN.19622 DIALNET GOOGLE SCHOLAR lock_openRUA editor

Outras publicacións en: Revista de Discapacidad, Clínica y Neurociencias: (RDCN)

Objetivos de desarrollo sostenible

Resumo

Alzheimer's disease (AD) is an irreversible neurodegenerative disease, accompanied by memory loss and progressive neurocognitive deficit. The pathophysiological changes associated with this disease are the extracellular formation of plaque deposits of the insoluble ß-amyloid peptide, the hyperphosphorylation of the tau protein forming neurofibrillary tangles, in addition to neuroinflammation, oxidative stress, alteration of energy metabolism, loss of neurons and synapses in brain. The pathogenesis of AD is not fully known because it is multifactorial. Therefore, there is no successful preventive treatment. In this sense, there is a recent interest in the bioactive compounds present in natural products and medicinal herbs for the treatment of AD due to their beneficial effects. The mangosteen, Garcinia mangostana L (Guttifereae family), is a tropical tree that produces an edible fruit with a sweet and spicy flavor; whose pericarp is a source of bioactive compounds, which have shown excellent pharmacological activity. The mangosteen pericarp has been used in traditional medicine against various diseases such as ulcers, skin infections, diarrhea or wounds. Many studies have reported that the mangosteen pericarp contains phenolic compounds, vitamins (B1, B2, C) and other bioactive substances. Xanthones and their derivatives belong to the polyphenol family, and are present in mangosteen. They have been shown to possess broad biological activity as antioxidants, anti- inflammatory, anticancer, antimicrobial, and neuroprotective activities in both in vitro and in vivo studies. Scientific evidence suggests that xanthones (obtained from mangosteen pericarp) may attenuate neurotoxicity and some of the pathophysiological changes associated with AD in both cell and animal models. In the present review, we describe the current status of the potential therapeutic effect of mangosteen extract and xanthones in cell and animal models in AD, in addition to describing the observed effects and the proposed molecular pathways.

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Fonte de datos: Dialnet