Histopathological and immunophenotypical characterization of a combined melanoma and mucoepidermoid carcinoma in a dog
- Martínez, M. C.
- Buendía Marín, Antonio Julian
- Sánchez Campillo, Joaquín
- Vilafranca, M.
- Altimira, J.
- Ramírez Zarzosa, Gregorio J.
- García, B.
- Navarro Cámara, José Antonio
ISSN: 0213-5434, 1989-1784
Argitalpen urtea: 2009
Zenbakia: 25
Orrialdeak: 135-142
Mota: Artikulua
Beste argitalpen batzuk: Anales de veterinaria de Murcia
Laburpena
The present paper reports the fi rst case of a canine high-grade (low differentiated) mucoepidermoid carcinoma, in which malignant proliferation of melanocytes has been detected. The tumoral mass was located in the lower neck, pressing against the 7th cervical vertebral body in an aged dog of mixed breed. No macroscopic signs of skin or oral melanoma or carcinoma were detected elsewhere. The microscopic examination showed close intermingling of the two components. Melanocytic proliferation rarely occurs accompanied by the colonization of nonmelanocytic tumors, and the cause of such proliferation remains unclear. In human pathology, several reports of pigmented mucoepidermoid carcinomas have been described, and in all cases the proliferation of the melanocytic component was considered as hyperplastic, and no sign of malignant proliferation was detected. However, neither in human nor in veterinary pathology has a case of intermingled melanoma and mucoepidermoid carcinoma been described.