Desarrollo de un modelo de infección intranasal en ratón utilizado para evaluar la protección inducida por diferentes vacunas frente a Chlamydophila Abortus
- Buendía, A.j. 1
- Nicolás, L. 1
- Navarro, J.A. 1
- Ortega, N. 1
- Gallego, M.C. 1
- Martínez, C.M. 1
- Sánchez, J. 1
- Caro, M.R. 1
- Cuello, F. 1
- Salinas, J. 1
- 1 Facultad de Veterinaria. Universidad de Murcia
- Fuente Crespo, Luis Fernando de la (coord.)
- Mariano Herrera García (coord.)
- Alfonso Abecia Martínez (coord.)
- María Jesús Alcalde Aldea (coord.)
- María Dolores Carro Travieso (coord.)
- Juan Francisco García Marín (coord.)
- Carlos Gonzalo Abascal (coord.)
- Valentín Pérez Pérez (coord.)
- Cristófol Peris Ribera (coord.)
- Luis Anel Rodríguez (coord.)
- Luis Rodríguez Ruiz (coord.)
Publisher: Consejería de Agricultura y Ganadería ; Junta de Castilla y León
ISBN: 84-934535-8-7
Year of publication: 2006
Pages: 271-273
Congress: Sociedad Española de Ovinotecnia y Caprinotecnia (SEOC). Jornadas (31. 2006. Zamora)
Type: Conference paper
Abstract
A new murine model of intranasal infection has been developed to serve as a tool for testing experimental vaccines. All the infected mice died by day 9 p.i. Three vaccines were tested, two killed vaccines, whose only difference was the chosen adjuvant (AlOH and QS-21), and a live vaccine. Results obtained with QS-21 vaccine show that the protection conferred by a killed vaccine could be as effective as a live vaccine, if the accurate adjuvant is chosen.