Estudio de los mecanismos moleculares implicados en la resistencia a quinolonas de Mycoplasma capricolum subsp. Capricolum
- Tatay-Dualde, J.
- PRATS-VAN DER HAM, M.
- De la Fe, C.
- Paterna, A.
- Sánchez, A.
- Corrales, J.C.
- Contreras, A.
- Gómez-Martín, A.
- M.ª Jesús Alcalde Aldea (coord.)
- Ceferina Vieira Aller (coord.)
- Juan José García García (coord.)
- Valentín Pérez Pérez (coord.)
- Raúl Bodas Rodríguez (coord.)
- Jesse Barandika (coord.)
Publisher: Ediciones Universidad de Salamanca ; Universidad de Salamanca
ISBN: 978-84-9012-793-3
Year of publication: 2017
Pages: 479-484
Congress: Sociedad Española de Ovinotecnia y Caprinotecnia (SEOC). Jornadas (42. 2017. Salamanca)
Type: Conference paper
Abstract
Quinolones interact with the bacterial DNA gyrase and topoisomerase IV, whosesubunits are encoded by two sets of genes (gyrA/gyrB and parC/parE), affecting DNAreplication. The aim of this work was to study the relationship between punctual changes at these genes and quinolone susceptibility of Mycoplasma capricolum subsp. capricolum.For this purpose, in vitro selected resistant mutants were studied. Changes associated tohigher minimum inhibitory concentration values were observed in gyrA, gyrB and parC.However, positions 83 and 80 of gyrA and parC respectively, showed a high association inthe acquisition of quinolone resistance in this bacterium.