Estudio del efecto del tratamiento tópico con diferentes formulaciones de curcumina sobre un modelo de reparación tisular en ratas Sprague-Dawley sanas y diabéticas

Zusammenfassung

The skin is undoubtedly the organ par excellence in human anatomy, by extension and by its involvement in multiple functions that include the synthesis of vitamin D. On many occasions, the integrity of the skin can be altered by different damaging mechanisms, which often lead to a wound. The objective of this experimental study has been to verify the efficacy of different formulations of curcumin in nanoparticles, applied in full thickness wounds in healthy rats (Sprague-Dawley) and in diabetic rats. The different preparations were applied daily to the wounds and a macroscopic evaluation of the wound diameter was made, as well as a histomorphometric and immunohistochemical study (only in diabetic rats) on days 3, 7 and 14. In the macroscopic study of healthy rats, faster healing was obtained in those treated with curcumin in hyaluronic acid (HA) -coated glyerosomes. The results of the histomorphometric variables demonstrated a clear trend towards early re-epithelialization of the group of healthy rats treated with curcumin in glycerides + HA, although no statistically significant differences were found (s.d.). The rest of the histomorphometric variables did not perform s.d. The immunohistochemical study did not reveal s.d. We conclude that the efficacy of curcumin encapsulation in glyerosomes + HA compared to other presentations was due to the achievement of a higher concentration of curcumin in the wound and greater stability, as well as the adjuvant effect of HA (anti-inflammatory and promoter of HA). cell mobility)