Modificaciones de la concentración de oxitetraciclina "in vitro" en función del tiempo y de la temperatura en plasma bovino

  1. M. E. Guimerá
  2. C. J. Ponferrada
  3. I. Rosado
  4. L. Moreno 1
  5. C. M. Cárceles
  6. J. M. Serrano
  1. 1 Universidad de Córdoba
    info

    Universidad de Córdoba

    Córdoba, España

    ROR https://ror.org/05yc77b46

Journal:
Acta Veterinaria

ISSN: 0214-039X

Year of publication: 1993

Volume: 7

Issue: 7

Pages: 37-44

Type: Article

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Abstract

The denaturalization of the antibiotics belonging to the tetracycline group has been a well-known fact since its discovery. The "in vitro" modification of the concentration of oxytetracycline in bovine plasma and phosphate buffer at temperature of 15, 25, 30, 37 and 42 degrees Celsius at different times has been investigated in this study. The modification of the concentration was found to occur mainly during the first hour and to be more manifest at lower concentrations of the antibiotic. Is was also found to be greater at lower temperatures in de case of the bovine plasma, and at higher temperatures in the case of the phosphate buffer. Aditionaly, the percentage of recuperation obtained alter freezing for prolonged periods of time were higher for low concentrations of the antibiotics.

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