Estudio farmacocinético de la oxitetraciclina en oveja y cabra

  1. Escudero Pastor, Elisa 1
  2. Ponferrada Abrisqueta, Carlos J.
  3. Gimerá, E.
  4. Serrano, J.M.
  5. Carlos Mario Cárceles Rodríguez 1
  1. 1 Universidad de Murcia
    info

    Universidad de Murcia

    Murcia, España

    ROR https://ror.org/03p3aeb86

Journal:
Anales de veterinaria de Murcia

ISSN: 0213-5434,  1989-1784

Year of publication: 1993

Issue: 9-10

Pages: 37-47

Type: Article

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Abstract

The pharmacokiiietic behavior of a conventional formulatioii of oxytetracycliiie was studied after intravenous administration to five sheep arid ten goats to determine if there are species differences in disposition. The antibiotic is distributed according to an open two-compartment model in both species. Thc plasnia drug concentration 1,s time following iniravenous administration of 10 nig/kg were best described by the biexponential equations C = 16.389 e ' h"" + 5.853 e-' lo"' for goats, and C = 18.658 e-' '"' + 6.158 e<' ' 16' for sheep. The half-lives for goats and sheep were 6 h 28 min and 6 h 9 min respectively and were not significantly different. The total body clearances for sheep and goats were 0.154 and 0.156 Llkglh respectively. There were significant dilferences between the apparent volumes of ihe peripheral compartmeni (Vp).

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