Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers

  1. Salazar, Eider
  2. Berriatua Fernández de Larrea, Eduardo
  3. Pérez, Marta
  4. Marín, Belén
  5. Acin Tresaco, Cristina
  6. Martín Burriel, Inmaculada
  7. Reina Arias, Ramsés
  8. Andrés Cara, Damián Fermín de
  9. Amorena Zabalza, Beatriz
  10. Badiola Díez, Juan José
  11. Luján Lerma, Lluís
Revista:
Spanish journal of agricultural research

ISSN: 1695-971X,  2171-9292

Año de publicación: 2014

Volumen: 12

Número: 3

Páginas: 676-682

Tipo: Artículo

DOI: 10.5424/SJAR/2014123-5489 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Otras publicaciones en: Spanish journal of agricultural research

Resumen

The relationship between Visna/maedi virus (VMV) antibody status and scrapie genetic resistance of 10,611 Rasa Aragonesa sheep from 17 flocks in Aragón (Spain) was investigated. The fifteen most common PRNP gene haplotypes and genotypes were identified and the genotypes were classified into the corresponding scrapie risk groups (groups 1 to 5). ARQ (93.3%) and ARR (31.8%) were the most common haplotypes and ARQ/ARQ (56%) and ARR/ARQ (25.6%) were the most common genotypes. The frequencies of scrapie risk groups 1, 2, 3, 4 and 5 were 3.3%, 27.3%, 63.5%, 1.2% and 4.8%, respectively. Overall Visna/maedi seroprevalence was 53% and flock seroprevalence ranged between 21-86%. A random effects logistic regression model indicated that sheep VMV serological status (outcome variable) was not associated with any particular scrapie risk group. Instead, VMV seropositivity progressively increased with age, was signif icantly greater in females compared to males and varied between flocks. The absence of a relationship between VMV infection and scrapie genotypes is important for VMV control and specifically for sheep participating in an ELISA-based Visna/maedi control program

Referencias bibliográficas

  • Acín C, Martín-Burriel I, Goldmann W, Lyahyai J, Monzón M, Bolea R, Smith A, Rodellar C, Badiola JJ, Zaragoza P, 2004. Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep. J Gen Virol 85: 2103-2110. http://dx.doi.org/10.1099/vir.0.80047-0
  • Álvarez L, Gutierrez-Gil B, San Primitivo F, de la Fuente F, Arranz JJ, 2006. Influence of prion protein genotypes on milk production traits in Spanish Churra sheep. J Dairy Sci 89: 1784-1791. http://dx.doi.org/10.3168/jds.S0022-0302(06)72247-0
  • Berriatua E, Álvarez V, Extramiana B, González L, Daltabuit M, Juste R, 2003. Transmission and control implications of seroconversión to Maedi-Visna virus in Basque dairy-sheep flocks. Prev Vet Med 12: 265-279. http://dx.doi.org/10.1016/S0167-5877(03)00163-6
  • Brinkhof J & van Maanen C, 2007. Evaluation of five enzyme-linked immunosorbent assays and an agar gel immunodiffusion test for detection of antibodies to small ruminant lentiviruses. Clin Vaccine Immunol 14: 1210-1214. http://dx.doi.org/10.1128/CVI.00282-06
  • Dawson M, Hoinville LJ, Hosie BD, Hunter N, 1998. Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie. Scrapie Information Group. Vet Record 142: 623-625.
  • de Vries F, Hamann H, Drögemüller C, Ganter M, Dist O, 2005. Analysis of associations between the prion protein genotypes and production traits in East Friesian milk sheep. J Dairy Sci 88: 392-398. http://dx.doi.org/10.3168/jds.S0022-0302(05)72699-0
  • Eaton SL, Rocchi M, González L, Hamilton S, Finlayson J, Sales J, Jeffrey M, Steele PJ, Dagleish, MP, Rodger SM et al., 2007. Immunological differences between susceptible and resistant sheep during the preclinical phase of scrapie infection. J Gen Virol 88: 1384-1391. http://dx.doi.org/10.1099/vir.0.82197-0
  • EFSA, 2006. Opinion of the Scientific Panel on Biological Hazards on "the breeding programme for TSE resistance in sheep". The EFSA Journal 382: 1-46.
  • Forsman A, Weiss RA, 2008. Why is HIV a pathogen? Trends Microbiol 16: 555-560. http://dx.doi.org/10.1016/j.tim.2008.09.004
  • González L, Martin S, Hawkins SA, Goldmann W, Jeffrey M, Sisó S, 2010. Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions. Vet Res 41: 48. http://dx.doi.org/10.1051/vetres/2010020
  • Gruner L, Elsen JM, Vu Tien Khang J, Eychenne F, Caritez JC, Jacquiet P, Andreoletti O, Sarradin P, Cortet J, Richer N et al., 2004. Nematode parasites and scrapie: experiments in sheep and mice. Parasitol Res 93: 493-498. http://dx.doi.org/10.1007/s00436-004-1131-7
  • Gudnadóttir M, 1974. Visna-Maedi in sheep. Progress Med Virol 18: 336-349.
  • Harrington RD, Herrmann-Hoesing LM, White SN, O'Rourke KI, Knowles DP, 2009. Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock. Gen Sel Evol 41: 17. http://dx.doi.org/10.1186/1297-9686-41-17
  • Huby M, Griffon L, Moreaux S, de Rochambeau H, Danchin-Burge C, Verrier E, 2003. Genetic variability of six French meat sheep breeds in relation to their genetic management. Gen Sel Evol 35: 637-655. http://dx.doi.org/10.1186/1297-9686-35-7-637
  • Lacroux C, Simon S, Benestad SL, Maillet S, Mathey J, Lugan S, Corbière F, Cassard H, Costes P, Bergonier D et al., 2008. Prions in milk from ewes incubating natural scrapie. PloS Pathog 4: e1000238. http://dx.doi.org/10.1371/journal.ppat.1000238
  • Leginagoikoa I, Daltabuit-Test M, Álvarez M, Arranz J, Juste RA, Amorena B, de Andrés D, Luján L, Badiola JJ, Berriatua E, 2006. Horizontal Maedi-Visna virus (MVV) infection in adult dairy-sheep raised under varying MVV-infection pressures investigated by ELISA and PCR. Res Vet Sci 80: 235-241. http://dx.doi.org/10.1016/j.rvsc.2005.05.003
  • Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, 2005. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med 11: 1137-1138. http://dx.doi.org/10.1038/nm1105-1137
  • OJ, 2001. Regulation (EC) No 999/2001 of the European Parliament and of the Council of 22 May 2001 laying down rules for the prevention, control and eradication of certain transmissible spongiform encephalopathies. Official Journal of the European Union No. 147, p 1-40.
  • OJ, 2003. Commission Decision of 13 February 2003 laying down minimum requirements for the establishment of breeding programmes for resistance to transmissible spongiform encephalopathies in sheep. Official Journal of the European Union No. 41, p 41-45.
  • Pérez M, Biescas E, de Andrés X, Leginagoikoa I, Salazar E, Berriatua E, Reina R, Bolea R, de Andrés D, Juste RA et al., 2010. Visna/maedi virus serology in sheep: Survey, risk factors and implementation of a successful control programme in Aragón. Vet J 186: 221-225. http://dx.doi.org/10.1016/j.tvjl.2009.07.031
  • Prusiner SB, 1982. Novel proteinaceous infectious particlescause scrapie. Science 216: 136-144. http://dx.doi.org/10.1126/science.6801762
  • Salazar E, Monleón E, Bolea R, Acín C, Pérez M, Álvarez N, Leginagoikoa I, Juste R, Minguijón E, Reina R et al., 2010. Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep. Vet Res 41: 58. http://dx.doi.org/10.1051/vetres/2010030
  • Saman E, van Eynde G, Luján L, Extramiana B, Harkiss G, Tolari F, González L, Watt N, Badiola J, 1999. A new sensitive serological assay for detection of lentivirus infections in small ruminants. Clin Diag Lab Immunol 6: 734-740.
  • Sweeney T, Hanrahan, JP, 2008. The evidence of associations between prion protein genotype and production, reproduction, and health traits in sheep-Review. Vet Res 39: 28. http://dx.doi.org/10.1051/vetres:2008004
  • Varea R, Monleón E, Pacheco C, Luján L, Bolea R, Vargas A, van Eynde G, Saman E, Dickson L, Harkiss G et al., 2001. Early detection of maedi-visna (ovine progressive pneumonia) virus seroconversion in field sheep samples. J Vet Diag Invest 13: 301-307. http://dx.doi.org/10.1177/104063870101300404
  • Vitezica ZG, Moreno CR, Lantier F, Lantier I, Schibler L, Roig A, Fran D, Cois F, Bouix J, Allain D et al., 2007. Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep. Gen Sel Evol 39: 421-430. http://dx.doi.org/10.1186/1297-9686-39-4-421
Fuente de los datos: Dialnet