Evaluación macroscópica y microscópica del efecto de la atorvastatina sobre la progresión-regresión de la esteatosis hepática en un modelo aviar

  1. A. Martín-Castillo 1
  2. B. García-Pérez 2
  3. I. Ayala 3
  4. G. Adánez 4
  5. J.V. Ortega 5
  6. M.T. Sánchez 2
  7. M.T. Castells 6
  1. 1 Sección de Aparato Digestivo. Hospital de Hellín. Hellín. Albacete. España
  2. 2 Servicio de Medicina Interna. Hospital Universitario Virgen de la Arrixaca. Murcia. España
  3. 3 Departamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad de Murcia. Murcia. España
  4. 4 Servicio de Urgencias. Hospital Universitario Virgen de la Arrixaca. Murcia. España
  5. 5 Servicio de Urgencias. Hospital de Los Arcos. San Pedro del Pinatar. Murcia. España
  6. 6 Departamento de Biología Celular. Facultad de Medicina. Universidad de Murcia. España
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Journal:
Clínica e investigación en arteriosclerosis

ISSN: 0214-9168,  1578-1879

Year of publication: 2005

Volume: 17

Issue: 6

Pages: 270-276

Type: Article

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Abstract

Introduction Nonalcoholic fatty liver disease is commonly associated with vascular disease secondary to statin therapy. Therefore, the development of a hepatic steatosis animal model could be useful to evaluate the effect of atorvastatin on induced hepatic lesions, as well as to provide macroscopic and microscopic methods for evaluating hepatic steatosis. Methods White Leghorn chickens were used, classified into five experimental groups, with different protocols of atorvastatin therapy and diets. Livers were assessed by means of macroscopic and microscopic analysis and classified into four grades of lesions. Results-conclusions The chicken is useful and suitable as an animal model of hepatic steatosis induced by an atherogenic diet. Two methods of assessment are described: macroscopic and microscopic analysis. It was concluded that macroscopic evaluation rapidly identifies the effect of diet; atorvastatin showed a beneficial effect, although this was not statistically significant. Histological analysis (by evaluation of lipidic deposits) provided a more detailed classification of the grades of lesion, especially in intermediate grades. The histological analysis showed a decrease in the severity of induced hepatic lesions in atorvastatin-treated groups. The combination of the two evaluation methods (macroscopic and microscopic) was useful for determining the grades of severity of hepatic steatosis.

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