Salivary myeloperoxidase and malondialdehyde are increased in patients exhibiting an asymptomatic mandibular impacted third molar

  1. Fabio Camacho Alonso 1
  2. María del Rosario Tudela-Mulero 2
  3. David Peñarrocha Oltra 3
  4. Miguel Peñarrocha Diago 4
  5. José Carlos Balaguer Martí 5
  6. Mariano Alberto Sánchez Siles 6
  1. 1 DDS, PhD, Department of Oral Surgery, University of Murcia, Murcia (Spain)
  2. 2 MR, BS, DDS, PhD, Department of Oral Surgery, University of Murcia, Murcia (Spain)
  3. 3 DDS, PhD. Department of Oral Surgery, University of Valencia, Valencia (Spain)
  4. 4 MD, DDS, PhD. Department of Oral Surgery, University of Valencia, Valencia (Spain)
  5. 5 DDS. Department of Oral Surgery, University of Valencia, Valencia (Spain)
  6. 6 DDS, PhD. In private oral surgery and medical practice, Murcia (Spain)
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Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2019

Volumen: 24

Número: 4

Páginas: 13

Tipo: Artículo

DOI: 10.4317/MEDORAL.22962 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Resumen

To determine whether saliva is a good means of evaluating concentrations of oxidative stress biomarkers, analyzing the correlation between concentrations in saliva and in follicular tissue, and to compare biomarker concentrations in patients with one asymptomatic mandibular impacted third molar (MITM) (before extraction) with a healthy control, and to determine how biomarkers are modified by extraction. 80 patients with one asymptomatic MITM and 80 healthy controls were included. Saliva samples were collected from all subjects (before extraction in the study group) to evaluate Myeloperoxidase (MPO) and Malondialdehyde (MDA) concentrations. Follicular tissues were obtained during surgery to measure biomarkers. One month after extraction, saliva samples were collected to assess changes of oxidative stress. Salivary MPO and MDA showed positive correlation with concentrations in follicular tissue (MPO: correlation coefficient=0.72, p=0.025; MDA: =0.92, p=0.001). Patients with asymptomatic MITMs showed higher salivary concentrations of oxidative stress biomarkers than healthy control subjects, with statistical significance for both MPO (p<0.001) and MDA (p<0.001). One month after extraction, salivary biomarkers decreased significantly in the study group (p<0.001). Salivary MPO and MDA are higher among patients with one asymptomatic MITM, but these levels decrease significantly one month after surgical extraction. The large decrease in oxidative stress biomarkers could justify third molar extraction despite the absence of symptoms.

Referencias bibliográficas

  • Güven, O,Keskin, A,Akal, ÜK. (2000). The incidence of cyst and tumors around impacted third molars. Int J Oral Maxilllfac Surg. 29. 131
  • Venta, I,Murtomaa, H,Turtola, L,Meurman, J,Ylipaavalniemi, P. (1991). Clinical follow-up study of third molar eruption from ages 20 to 26 years. Oral Surg Oral Med Oral Pathol. 72. 150
  • Wang, D,He, X,Wang, Y,Li, Z,Zhu, Y,Sun, C. (2017). External root resorption of the second molar associated with mesially and horizontally impacted mandibular third molar: evidence from cone beam computed tomography. Clin Oral Investig. 21. 1335
  • Adeyemo, WL. (2006). Do pathologies associated with impacted lower third molars justify prophylactic removal? A critical review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 102. 448
  • Lopes, V,Mumernya, R,Feinmann, C,Harris, M. (1995). Third molar surgery: an audit of indications for surgery, post-operative complications and patient satisfaction. Br J Oral Maxillofac Surg. 33. 33
  • Srivastava, N,Shetty, A,Goswami, RD,Apparaju, V,Bagga, V,Kale, S. (2017). Incidence of distal caries in mandibular second molars due to impacted third molars: Nonintervention strategy of asymptomatic third molars causes harm? A retrospective study. Int J Appl Basic Med Res. 7. 15
  • (1980). NIH consensus development conference for removal of third molars. J Oral Surg. 38. 235
  • Lysell, R,Rohlin, M. (1988). A study of indications used for removal of the mandibular third molar. Int J Oral Maxillofac Surg. 17. 161
  • Eliasson, S,Heimdahl, A,Nordenram, A. (1989). Pathological changes related to long-term impaction of third molars. Int J Oral Maxillofac Surg. 18. 210
  • Brkić, A,Mutlu, S,Koçak-Berberoğlu, H,Olgaç, V. (2010). Pathological changes and immunoexpression of p63 gene in dental follicles of asymptomatic impacted lower third molars: an immunohistochemical study. J Craniofac Surg. 21. 854
  • Cabbar, F,Güler, N,Comunoğlu, N,Sençift, K,Cöloğlu, S. (2008). Determinatioin of potential cellular proliferation in the odontogenic epithelia of dental follicle of the aymptomatic impacted third molars. J Oral Maxillofac Surg. 66. 2004
  • Hendek, MK,Şenses, F,Kisa, Ü,Aksoy, N,Tekin, U. (2017). Is the Level of Nitric Oxide in the Dental Follicular Tissues of Impacted Third Molars With a History of Recurrent Pericoronaritis a True Marker of Oxidative Stress?. J Oral Maxillofac Surg. 75. 2058
  • Chisci, G,De Felice, C,Parrini, S,Signorini, C,Leoncini, S,Ciccoli, L. (2013). The role of preoperative oxidative stress and mandibular third molar postoperative outcome. Int J Oral Maxillofac Surg. 42. 1499
  • Tekin, U,Kısa, Ü,Güven, O,Kurku, H. (2011). Malondialdehyde levels in dental follicles of asymptomatic impacted third molars. J Oral Maxillofac Surg. 69. 1291
  • Winterbourn, CC,Vissers, MC,Kettle, AJ. (2000). Myeloperoxidase. Curr Opin Hematol. 7. 53
  • Trachootham, D,Lu, W,Ogasawara, MA,Nilsa, RD,Huang, P. (2008). Redox regulation of cell survival. Antioxid Redox Signal. 10. 1343
  • Alemany-Martínez, A,Valmaseda-Castellón, E,Berini-Aytés, L,Gay-Escoda, C. (2008). Hemodynamic changes during the surgical removal of lower third molars. J Oral Maxillofac Surg. 66. 453
  • Tsimikas, S. (2006). Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease. Am J Cardiol. 98. 9-17
  • Block, G,Dietrich, M,Norkus, EP,Morrow, JD,Hudes, M,Caan, B. (2002). Factors associated with oxidative stress in human populations. Am J Epidemiol. 156. 274
  • Souza, MH,Troncon, KE,Cunha, FQ,Oliveira, RB. (2003). Decreased gastric tone and delayed gastric emptying precede neutrophil infiltration and mucosal lesion formation in indomethacin-induced gastric damage in rats. Braz J Med Biol Res. 36. 1383
  • Araújo, AA,Souza, TO,Moura, LM,Brito, GA,Aragão, KS,Araújo, LS. (2013). Effect of telmisartan on levels of IL-1, TNF-α, down-regultated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model. J Clin Periodontol. 40. 1104
  • Stathopoulos, P,Mezitis, M,Kappatos, C,Titsinides, S,Stylogianni, E. (2011). Cysts and tumours associated with impacted third molars: is prophylactic removal justified?. J Oral Maxillofac Surg. 69. 405
  • Al-khateeb, TH,Bataineh, AB. (2006). Pathology associated with impacted mandibular third molars in a group of Jordains. J Oral Maxillofac. 64. 1598
  • Van der Sandem, WJ,Mettes, DG,Plasschaert, AJ,Grol, RP,Mulder, J,Verdonschot, EH. (2005). Effectiveness of clinical practice guideline implamentation on lower third molar management in improving clinical decision-making: a randomized controlled trial. Eur J Oral Sci. 113. 349
  • Song, F,O'Meara, S,Wilson, P,Golder, S,Kleijnen, J. (2000). The effectiveness and cost-effectiveness of prophylactic removal of wisdom teeth. Health Technol Assess. 4. 1-55
  • Costa, MG,Pazzini, CA,Pantuzo, MC,Jorger, ML,Marques, LS. (2013). Is there justificacion for prophylactic extraction of third molars? A systematic review. Braz Oral Res. 27. 183
  • Esen, A,Isik, K,Findik, S,Suren, D. (2016). Histopathological evaluation of dental follicles of clinically symptomatic and asymptomatic impacted third molars. Niger J Clin Pract. 19. 616
  • Giebułtowicz, J,Wroczyński, P,Samolczyk-Wanyura, D. (2013). Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer?. Oral Dis. 19. 763
  • Graziani, F,D'Aiuto, F,Gennai, S,Petrini, M,Nisi, M,Cirigliano, N. (2017). Systemic Inflammation after Third Molar Removal: A Case-Control Study. J Dent Res. 96. 1505
  • Sánchez-Siles, M,Lucas-Azorin, J,Salazar-Sánchez, N,Carbonell-Meseguer, L,Camacho-Alonso, F. (2016). Salivary Concentration of Oxidative Stress Biomarkers in a Group of Patients with Peri-Implantitis: A Transversal Study. Clin Implant Dent Relat Res. 18. 1015
Fuente de los datos: Dialnet