Alteraciones morfológicas del tiroides de ratas Wistar macho, tratadas con estradiol y acetato de trenbolona

Résumé

Structural and ultrastructural modifications in thyroid parenchyme of rats treated with oestradiol and trenbolone acetate have been' studied. Thirty-five male Wistarrats were used as material ofstudy distnbuted in twogroups: one of28animals divided in seven lots of four animals each, and other of seven animals used as witness. In every rat of the first group a tablet containing 2'5 mg of oestradiol and 17'5 mg of trenbolone acetate was implanted subcutaneously behind the ear. Both gruops were sacrified on the first, third, fifth, seventh, fifteenth, thirtieth and sixtieth day postimplantation. Thyroid gland shows a hyperactivity in the first experimentation lot, characterized by an increase in al1 gland stmctures where there is a predominance of synthesis follicles. In lots 4 and 5 a foUicular djsorganization and bocicgenic or follicular hyperplasia is observed, due toa decrease of gland structures, appearing a great follicular disorganization both at central and periferic level, with a great amount of follicles without colloid seeming-like mosaic cells. In the last two lots. those of days 30th and 60th, afollicular recovering is found with agreat amount of stonngfollicles lined by flat cells and with clear indications of cellular regeneration, so a colloid goitre is set up.