Development and evolution of the vertebrate hypothalamusevidences in chondrichthyans

  1. Santos Durán, Gabriel Nicolás
Dirigida per:
  1. Isabel Rodríguez-Moldes Codirector/a
  2. Eva Candal Suárez Codirector/a

Universitat de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 18 de de desembre de 2015

Tribunal:
  1. Ramon Anadon Vazquez President/a
  2. Manuel A. Pombal Diego Secretari/ària
  3. Philippe Vernier Vocal
  4. Luis V. Puelles López Vocal
  5. Agustín González Gallegos Vocal

Tipus: Tesi

Teseo: 400310 DIALNET lock_openMINERVA editor

Resum

The hypothalamus is a conserved integrative center with a complex organization result of a complex patterning processes. Here we make use of a evo-devo approach and the theoretical framework of the prosomeric model to understand the organization of the vertebrate hypothalamus. We studied the gene expression patterns of ScFoxg1a, ScDlx2/5, ScOtp, ScShh, ScNkx2.1, ScTbr1, ScNeurog2, ScLhx5, ScLhx9, ScDlx2/5, ScNkx2.8, ScEmx2, ScLmx1b, ScPitx2, ScPitx3a, ScNeurog2, ScFoxa1 and ScFoxa2 besides immunoreactivity to Pax6, PCNA and other immunomarkers in the embryonic hypothalamus and neighbour prosencephalic territories of a cartilaginous fish, the catshark, Scyliorhinus canicula. Our comparative analysis reveals the existence of conserved traits but also suggests an alternative organization to that proposed by the prosomeric model for the hypothalamus and even for the anterior prosencephalon of vertebrates.