Children with obesity have poorer circadian health as assessed by a global circadian health score

  1. Rodríguez-Martín, María
  2. Martínez-Lozano, Nuria
  3. Santaclara-Maneiro, Vicente
  4. Gris-Peñas, Antonio
  5. Salmerón, Diego
  6. Ríos, Rafael
  7. Tvarijonaviciute, Asta
  8. Garaulet, Marta
Journal:
World Journal of Pediatrics

ISSN: 1708-8569,  1867-0687

Year of publication: 2024

Volume: 20

Issue: 8

Pages: 787-800

Type: Article

DOI: 10.1007/S12519-024-00804-3 SCOPUS: 2-s2.0-85195428677 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: World Journal of Pediatrics

Abstract

Background: Circadian health refers to individuals’ well-being and balance in terms of their circadian rhythm. It is influenced by external cues. In adults, a close relationship between circadian-related alterations and obesity has been described. However, studies in children are scarce, and circadian health and its association with obesity have not been evaluated globally. We aimed to assess whether circadian health differed between children with and without obesity as determined by a global circadian score (GCS) in a school-age population. Methods: Four hundred and thirty-two children (7–12 years) were recruited in Spain. Non-invasive tools were used to calculate the GCS: (1) 7-day rhythm of wrist temperature (T), activity (A), position (P), an integrative variable that combines T, A, and P (TAP); (2) cortisol; and (3) 7-day food and sleep records. Body mass index, body fat percentage, waist circumference (WC), melatonin concentration, and cardiometabolic marker levels were determined. Results: Circadian health, as assessed by the GCS, differed among children with obesity, overweight, and normal weight, with poorer circadian health among children with obesity. Children with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health, respectively, than did those with normal weight or low WC. The percentage of rhythmicity, a marker of the robustness of the TAP rhythm, and the amplitude, both components of the GCS, decreased with increasing obesity. Different lifestyle behaviors were involved in the association between circadian health and obesity, particularly protein intake (P = 0.024), physical activity level (P = 0.076) and chronotype (P = 0.029). Conclusions: The GCS can capture the relationship between circadian health and obesity in school-age children. Protein intake, physical activity level, and chronotype were involved in this association. Early intervention based on improving circadian health may help to prevent childhood obesity.

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Funding information

Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was supported by the Spanish Society for the Study of Obesity (SEEDO) with the award of the 1st XLS Medical Scholarship for obesity research and by the Spanish Government of Investigation, Development and Innovation (SAF2017-84135-R) including FEDER co-funding, the Autonomous Community of the Region of Murcia through the Seneca Foundation (20795/PI/18) and NIDDK R01DK105072 granted to Marta Garaulet.

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