Pharmacokinetics of Doxycycline in Alpacas After Intravenous and Subcutaneous Administration

  1. Martínez, José 2
  2. Marín, Pedro 2
  3. Egas, David A. 4
  4. Llivi-Marcatoma, Juan 1
  5. Mira-Naranjo, José Miguel 1
  6. Badillo, Elena 2
  7. Yuste, María Teresa 2
  8. Escudero, Elisa 2
  9. Galecio, Juan Sebastián 3
  1. 1 Escuela de Medicina Veterinaria, Facultad de Ciencias Pecuarias, Escuela Superior Politécnica de Chimborazo, Panamericana Sur Km 1 1/2, Riobamba 060106, Ecuador
  2. 2 Department of Pharmacology, Campus de Espinardo, University of Murcia, 30100 Murcia, Spain
  3. 3 Escuela de Medicina Veterinaria, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Cumbayá 170901, Ecuador
  4. 4 Colegio de Ciencias e Ingenieras, Universidad San Francisco de Quito, Cumbayá 170901, Ecuador
Journal:
Antibiotics

ISSN: 2079-6382

Year of publication: 2025

Volume: 14

Issue: 3

Pages: 247

Type: Article

DOI: 10.3390/ANTIBIOTICS14030247 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Antibiotics

Bibliographic References

  • Cuadros Arevalo, C.d.M. (2023). Opciones de Adaptación Que inciden en el Volumen de Fibra de Alpaca en Comunidades Alpaqueras de Puno, Provincia de Lampa, Universidad Nacional de San Agustín.
  • Lupton, (2006), Small Rumin. Res., 64, pp. 211, 10.1016/j.smallrumres.2005.04.023
  • Esquivel, (2018), S. Am. Camelids, 11, pp. 30
  • Quispe, (2009), Anim. Genet. Resour. Inf., 45, pp. 1, 10.1017/S1014233909990277
  • Wang, X., Wang, L., and Liu, X. (2003). The Quality and Processing Performance of Alpaca Fibres.
  • (2013), Rev. Complut. Cienc. Vet., 7, pp. 1
  • Bartl, (2023), Sci. Total Environ., 905, pp. 167023, 10.1016/j.scitotenv.2023.167023
  • (2019), IOP Conf. Ser. Mater. Sci. Eng., 689, pp. 012010, 10.1088/1757-899X/689/1/012010
  • Ministerio de Desarrollo Agrario y Riego (2021). Tops de Alpaca Hilados Prendas de Vestir Análisis de Mercado 2016–2020.
  • Johnson, (1989), Vet. Clin. N. Am. Food Anim. Pract, 5, pp. 37, 10.1016/S0749-0720(15)31002-1
  • Fernández Baca, S. (2005). Situación Actual de Los Camélidos Sudamericanos en Perú, FAO.
  • Davis, (1998), Vet. Rec., 142, pp. 162, 10.1136/vr.142.7.162
  • Espada, (2010), Rev. Complut. Cienc. Vet., 4, pp. 37
  • Konieczny, K., and Pomorska-Mól, M. (2024). A literature review of selected bacterial diseases in alpacas and llamas—Epidemiology, clinical signs and diagnostics. Animals, 14.
  • Delacruz, (2023), Granja, 37, pp. 73
  • Karol, (2013), Rev. Investig. Veterinarias Perú, 24, pp. 524
  • Adams, (1994), Vet. Clin. N. Am. Food Anim. Pract., 10, pp. 209, 10.1016/S0749-0720(15)30556-9
  • Whitehead, (2006), Small Ruminant Res., 61, pp. 207, 10.1016/j.smallrumres.2005.07.012
  • Cebra, (2003), J. Am. Vet. Med. Assoc., 223, pp. 1806, 10.2460/javma.2003.223.1806
  • Cebra, C.K., and Cebra, M.L. (2013). Antimicrobial drug use in New World camelids. Antimicrobial Therapy in Veterinary Medicine, Wiley.
  • Rizzo, (2023), Curr. Pharm. Des., 29, pp. 312, 10.2174/1381612829666230130144731
  • (2025, January 15). Regulation (EU) 2019/6 of the European Parliament and of the Council of 11 December 2018 on Veterinary Medicinal Products and Repealing Directive 2001/82/EC (Text with EEA Relevance), Available online: https://www.legislation.gov.uk/eur/2019/6/contents.
  • Caneschi, A., Bardhi, A., Barbarossa, A., and Zaghini, A. (2023). The Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine, a Complex Phenomenon: A Narrative Review. Antibiotics, 12.
  • EMA (2019). Answer to the Request from the European Commission for Updating the Scientific Advice on the Impact on Public Health and Animal Health of the Use of Antibiotics in Animals–Categorisation of Antimicrobials, EMA. EMA/CVMP/CHMP/682198/2017.
  • del Castillo, J.R.E. (2013). Tetracyclines. Antimicrobial Therapy in Veterinary Medicine, Wiley.
  • Mileva, R., and Milanova, A. (2022). Doxycycline pharmacokinetics in mammalian species of veterinary interest—An overview. Bulg. J. Vet. Med., 25.
  • Martínez, J., Escudero, E., Badillo, E., Yuste, M.T., Galecio, J.S., and Marin, P. (2024). Pharmacokinetics of Doxycycline in Plasma and Milk after Intravenous and Intramuscular Administration in Dairy Goats. Animals, 14.
  • Escudero, (2024), Res. Vet. Sci., 180, pp. 105412, 10.1016/j.rvsc.2024.105412
  • Turk, E., Corum, O., Tekeli, I.O., Sakin, F., and Uney, K. (2020). Effects of Single and Repeated Doses on Disposition and Kinetics of Doxycycline Hyclate in Goats. Animals, 10.
  • Ocampo, (2014), J. Vet. Pharmacol. Ther., 37, pp. 83, 10.1111/jvp.12066
  • Sumano, (2008), Res. Vet. Sci., 84, pp. 477, 10.1016/j.rvsc.2007.07.003
  • Meijer, (1993), Vet. Q., 15, pp. 1, 10.1080/01652176.1993.9694358
  • Davis, (2006), Am. J. Vet. Res., 67, pp. 310, 10.2460/ajvr.67.2.310
  • Castro, (2009), Vet. J., 180, pp. 389, 10.1016/j.tvjl.2008.02.001
  • Chapuis, R.J.J., Smith, J.S., French, H.M., Toka, F.N., Peterson, E.W., and Little, E.L. (2021). Nonlinear Mixed-Effect Pharmacokinetic Modeling and Distribution of Doxycycline in Healthy Female Donkeys after Multiple Intragastric Dosing–Preliminary Investigation. Animals, 7.
  • Oukessou, (1992), Am. J. Vet. Res., 53, pp. 1658, 10.2460/ajvr.1992.53.09.1658
  • (2003), Pak. Vet. J., 23, pp. 187
  • Hund, A., Wittek, T., Selan, U., Käsbohrer, A., and Firth, C.L. (2023). Most common diagnoses and antibiotics used in South American Camelid patients at a university clinic in Austria. Front. Vet. Sci., 10.
  • Thedford, (1989), Vet. Clin. N. Am. Food Anim. Pract., 5, pp. 145, 10.1016/S0749-0720(15)31007-0
  • Christensen, (1996), J. Vet. Pharmacol. Ther., 19, pp. 431, 10.1111/j.1365-2885.1996.tb00079.x
  • Cebra, C., Anderson, D.E., Tibary, A., Van Saun, R.J., and Johnson, L.W. (2013). Llama and Alpaca Care: Medicine, Surgery, Reproduction, Nutrition, and Herd Health, Elsevier Inc.. [1st ed.].
  • Gandolf, (2005), Am. J. Vet. Res., 66, pp. 767, 10.2460/ajvr.2005.66.767
  • Riond, (1989), Am. J. Vet. Res., 50, pp. 1329, 10.2460/ajvr.1989.50.08.1329
  • Vargas, (2008), Am. J. Vet. Res., 69, pp. 1131, 10.2460/ajvr.69.8.1085
  • Goudah, (2004), Pharmacol. Res., 49, pp. 487, 10.1016/j.phrs.2003.10.012
  • Toutain, (2004), J. Vet. Pharmacol. Ther., 27, pp. 455, 10.1111/j.1365-2885.2004.00604.x
  • Nightingale, C.H., Murakawa, T., and Ambrose, P.G. (2002). Pharmacodynamics of Antimicrobials: General Concepts and Applications. Antimicrobial Pharmacodynamics in Theory and Clinical Practice, Marcel Dekker, Inc.. [2nd ed.].
  • Cunha, (2000), Clin. Microbiol. Infect., 6, pp. 270, 10.1046/j.1469-0691.2000.00058-2.x
  • Zhang, H., Mao, C., Li, J., Huang, Z., Gu, X., Shen, X., and Ding, H. (2019). Pharmacokinetic/pharmacodynamic integration of doxycycline against Mycoplasma hyopneumoniae in an in vitro model. Front. Pharmacol., 10.
  • Zhang, (2016), Front. Microbiol., 7, pp. 653
  • McKellar, (2004), J. Vet. Pharmacol. Ther., 27, pp. 503, 10.1111/j.1365-2885.2004.00603.x
  • Zhang, (2018), J. Vet. Pharmacol. Ther., 41, pp. 706, 10.1111/jvp.12512
  • Toutain, (2002), J. Vet. Pharmacol. Ther., 25, pp. 460, 10.1046/j.1365-2885.2002.00442.x
  • Toutain, (2021), J. Vet. Pharmacol. Ther., 44, pp. 172, 10.1111/jvp.12917
  • Sting, R., Schwabe, I., Kieferle, M., Münch, M., and Rau, J. (2022). Fatal infection in an alpaca (Vicugna pacos) caused by pathogenic Rhodococcus equi. Animals, 12.
  • Sting, R., Geiger, C., Rietschel, W., Blazey, B., Schwabe, I., Rau, J., and Schneider-Bühl, L. (2022). Corynebacterium pseudotuberculosis infections in alpacas (Vicugna pacos). Animals, 12.
  • Hernandis, (2024), Acta Vet. Beograd., 74, pp. 511, 10.2478/acve-2024-0035
  • Food and Drug Administration (2024, July 26). Bioanalytical Method Validation-Guidance for Industry. US Department of Health and Human Services, Available online: https://www.fda.gov/files/drugs/published/Bioanalytical-Method-Validation-Guidance-for-Industry.pdf.