Síndromes mielodisplásicos
- Cabañas Perianes, Valentín
- Salido Fiérrez, E.
- García Candel, F.
- Moraleda Jiménez, José María
ISSN: 0304-5412
Year of publication: 2012
Issue Title: Enfermedades de la sangre (II): enfermedades de los leucocitos
Series: 11
Issue: 21
Pages: 1280-1288
Type: Article
More publications in: Medicine: Programa de Formación Médica Continuada Acreditado
Sustainable development goals
Abstract
Myelodysplastic syndromes (MOS) are a heterogeneous group of clonal hematological malignancies characterized by an impaired morphology and maturation of the bone marrow hematopoietic precursors (dysmyelopoiesis) causing an ineffective blood cell production and cytopenias. These disorders often occur in elderly patients and the etiology is unknown in most cases. Patients with MOS may present with clinical manifestations of anemia, thrombocytopenia (bleeding) and/or leukopenia Iintectionsl. The clinical course and survival is variable depending on the subtype of MOS and there is a subgroup of patients that often progresses to acute leukemia. Standard treatment is supportive care including transfusions and colony stimulating factors, and may include chemotherapy, immunomodulators and hypometilating agents, although allogeneic bone marrow transplantation is the only curative treatment.